Health Effects of Depleted Uranium (DU): A review of the Recent Research, 91outcomes.com: by Anthony Hardie, 20 July 2010, The studies examine DU that has been embedded/implanted (such as shrapnel) in the body, ingested/swallowed and absorbed into the body, and inhaled into the upper and/or lower respiratory tracts/lungs. One study examines DU exposure through wounds. None of the studies examines the effect on the skin from contact with DU, DU particulate matter, or DU crystalline residue.Taken together, the studies suggest that there are different health outcomes depending on how the DU comes into contact with the body, with a wide range of effects………
DU Genotoxity. Some substances have genotoxic properties – properties that make them harmful to the genetic information (DNA, RNA, chromosomes, etc.) in living creatures. There are three types of genotoxins: 1) Carcinogens (cancer-causing); 2) Mutagens (cause mutations); and, 3) Teratogens (birth-defect causing).
A Chinese government study using rats fed levels of DU, ranging from none to high, found increased concentrations of uranium in the kidneys and ovaries and significant abnormalities in the sperm in those that had consumed the DU. Because these genotoxic changes to the DNA affected ovaries and sperm, the DNA changes were passed on to offspring, even for rats that had consumed only low doses of DU, with the most severe changes in the sperm found in the offspring of the rats exposed to DU, even at low levels. (Y. Hao, 2009)………..
Effects of Inhaled DU. A new study from the Wise Laboratory of Environmental and Genetic Toxicology in Maine found that DU caused cellular death in the cells lining the bronchial airways of human lungs, and caused damage to the chromosomes after just 48 hours…..
A second study published by the same group found even stronger evidence of the damage caused by DU to human lungs, showing that the cells lining the airways are “transformed by DU and exhibit significant chromosome instability consistent with” the growth of neoplasms — abnormal growth of cells that, if large enough, are known as “tumors.” Neoplasms are of three types: non-malignant, pre-malignant, and malignant. (H. Xie et al, 2010)……….
Particles in the PM2.5 size range are able to travel deeply into the respiratory tract, reaching the lungs. Exposure to fine particles can cause short-term health effects such as eye, nose, throat and lung irritation, coughing, sneezing, runny nose and shortness of breath. Exposure to fine particles can also affect lung function and worsen medical conditions such as asthma and heart disease. Scientific studies have linked increases in daily PM2.5 exposure with increased respiratory and cardiovascular hospital admissions, emergency department visits and deaths. Studies also suggest that long term exposure to fine particulate matter may be associated with increased rates of chronic bronchitis, reduced lung function and increased mortality from lung cancer and heart disease. People with breathing and heart problems, children and the elderly may be particularly sensitive to PM2.5. (Source: NY Dept. of Health)
Effects of Implanted/Embedded DU. Urine testing of approximately 1,7000 U.S. veterans found three with evidence of DU in their urine; all three had embedded DU fragments. (CD Dorsey et al, 2009)………….
A Fudan University (China) study concluded that kidneys and bone are the primary reservoirs for uranium redistributed from DU fragments embedded in muscle, and “the accumulations in kidney, bone and many other tissues suggest the potential for unanticipated physiological consequences of chronic exposure to DU.” (G. Zhu et al, 2009)………….
Leukemia and DU. A U.S. Department of Defense, Armed Forces Radiobiology Research Institute (AFFRI) study of mice with leukemia induced by chronic internal exposure to DU found that non-genetic factors causing genes to behave (or “express themselves”) differently are implicated in DU-induced leukemia. The study found evidence that a form of abnormal activity, called hypomethylation, in the DNA in the spleen was associated with both the chronic internal DU exposure and the onset of leukemia, a new link between DU and leukemia. (Miller et al, 2009)……….
A U.S. Army Center for Health Promotion and Preventive Medicine (USA CHPPM) Capstone study discussed its development of a test that determines the approximate severity of effect on the kidneys following DU exposure with 85 percent accuracy. The study asserted that, “The primary target for uranium toxicity is the kidney.” (Roszell et al, 2009)
91outcomes.com: Health Effects of Depleted Uranium (DU): A review of the Recent Research