New research shows how low dose ionising radiation promotes cancer

Low doses of radiation promote cancer-capable cells, Science Daily 

New research in mice helps to understand the risks around exposure to low doses of radiation, such as CT scans and X-rays

Date

July 18, 2019

Source:

Wellcome Trust Sanger Institute

Summary:

New research finds that low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells.

Low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells in healthy tissue, scientists have discovered. Researchers at the Wellcome Sanger Institute and the University of Cambridge studied the effects of low doses of radiation in the esophagus of mice.

The team found that low doses of radiation increase the number of cells with mutations in p53, a well-known genetic change associated with cancer. However, giving the mice an antioxidant before radiation promoted the growth of healthy cells, which outcompeted and replaced the p53 mutant cells.

The results, published today (18 July) in Cell Stem Cell show that low doses of radiation promote the spread of cancer-capable cells in healthy tissue. Researchers recommend that this risk should be considered in assessing radiation safety. The study also offers the possibility of developing non-toxic preventative measures to cut the risk of developing cancer by bolstering our healthy cells to outcompete and eradicate cancer-capable cells……..

Low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells in healthy tissue, scientists have discovered. Researchers at the Wellcome Sanger Institute and the University of Cambridge studied the effects of low doses of radiation in the esophagus of mice.

The team found that low doses of radiation increase the number of cells with mutations in p53, a well-known genetic change associated with cancer. However, giving the mice an antioxidant before radiation promoted the growth of healthy cells, which outcompeted and replaced the p53 mutant cells.

The results, published today (18 July) in Cell Stem Cell show that low doses of radiation promote the spread of cancer-capable cells in healthy tissue. Researchers recommend that this risk should be considered in assessing radiation safety. The study also offers the possibility of developing non-toxic preventative measures to cut the risk of developing cancer by bolstering our healthy cells to outcompete and eradicate cancer-capable cells…….

Dr Kasumi Murai, an author from the Wellcome Sanger Institute, said: “Giving mice an antioxidant before exposing them to low doses of radiation gave healthy cells the extra boost needed to fight against the mutant cells in the esophagus and make them disappear. However, we don’t know the effect this therapy would have in other tissues — it could help cancer-capable cells elsewhere become stronger. What we do know is that long term use of antioxidants alone is not effective in preventing cancer in people, according to other studies.” … https://www.sciencedaily.com/releases/2019/07/190718150933.htm